MOSClip Tutorials

Welcome to MOSClip tutorial series!

MOSClip is an R package that allows performing multi-omic survival analysis exploiting pathway topology.

Start guide

If you are looking for tutorials you are in the right place.

In this section you can find a series of tutorials:

• how to download data from TCGA
• how to format the dataset for MOSClip (Needs functions-to-process-TCGA-data.R in the downloadTCGA directory)
• how to perform a two-class analysis

Data availability

You can download the data generated in these tutorials.

• pre-processed ovarian cancer dataset
• reactome pathways (EntrezIDs)
• two-class analysis results

Installation

You can install MOSClip from Bioconductor.

# Install the package from Bioconductor
if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("MOSClip")

References

Paolo Martini, Monica Chiogna, Enrica Calura, and Chiara Romualdi. 2019. “MOSClip: Multi-Omic and Survival Pathway Analysis for the Identification of Survival Associated Gene and Modules.” Nucleic Acids Research 47 (14): e80. https://doi.org/10.1093/nar/gkz324