TP53 Regulates Transcription of Cell Death Genes

GLI proteins bind promoters of Hh responsive genes to promote transcription

Signaling by Ligand-Responsive EGFR Variants in Cancer

Signaling by Overexpressed Wild-Type EGFR in Cancer

Inhibition of Signaling by Overexpressed EGFR

APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

PCNA-Dependent Long Patch Base Excision Repair

Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)

Termination of translesion DNA synthesis

Defective SLC7A7 causes lysinuric protein intolerance (LPI)

Defective SLC7A9 causes cystinuria (CSNU)

Diseases of signal transduction by growth factor receptors and second messengers

RHO GTPases Activate Rhotekin and Rhophilins

Constitutive Signaling by AKT1 E17K in Cancer

Negative feedback regulation of MAPK pathway

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome

Defective ABCG8 causes GBD4 and sitosterolemia

Defective ABCC8 can cause hypo- and hyper-glycemias

HDR through Single Strand Annealing (SSA)

HDR through Homologous Recombination (HRR)

Diseases associated with surfactant metabolism

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

Resolution of D-loop Structures through Holliday Junction Intermediates

Homologous DNA Pairing and Strand Exchange

Processing of DNA double-strand break ends

Presynaptic phase of homologous DNA pairing and strand exchange

Gap-filling DNA repair synthesis and ligation in GG-NER

Global Genome Nucleotide Excision Repair (GG-NER)

Deposition of new CENPA-containing nucleosomes at the centromere

Highly sodium permeable postsynaptic acetylcholine nicotinic receptors

Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Highly calcium permeable nicotinic acetylcholine receptors