TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

Downregulation of SMAD2/3:SMAD4 transcriptional activity

NOTCH2 intracellular domain regulates transcription

Constitutive Signaling by Aberrant PI3K in Cancer

Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

Activation of gene expression by SREBF (SREBP)

The canonical retinoid cycle in rods (twilight vision)

Establishment of Sister Chromatid Cohesion

Activation of the phototransduction cascade

Inactivation, recovery and regulation of the phototransduction cascade

Formation of Senescence-Associated Heterochromatin Foci (SAHF)

DNA Damage/Telomere Stress Induced Senescence

Regulation of PLK1 Activity at G2/M Transition

Signaling by NOTCH1 PEST Domain Mutants in Cancer

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Caspase-mediated cleavage of cytoskeletal proteins

Signaling by NOTCH1 HD Domain Mutants in Cancer

Constitutive Signaling by NOTCH1 HD Domain Mutants

Role of LAT2/NTAL/LAB on calcium mobilization

POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation

Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

NOTCH2 Activation and Transmission of Signal to the Nucleus

Initiation of Nuclear Envelope (NE) Reformation

SUMOylation of DNA damage response and repair proteins

SUMO E3 ligases SUMOylate target proteins

Regulation of innate immune responses to cytosolic DNA

Defects in vitamin and cofactor metabolism

Detoxification of Reactive Oxygen Species

Regulation of HSF1-mediated heat shock response

Autodegradation of the E3 ubiquitin ligase COP1

Regulation of ornithine decarboxylase (ODC)

Apoptotic cleavage of cell adhesion  proteins

Amino acid transport across the plasma membrane

GRB2:SOS provides linkage to MAPK signaling for Integrins

Diseases associated with glycosaminoglycan metabolism

Defective B4GALT7 causes EDS, progeroid type

Defective EXT1 causes exostoses 1, TRPS2 and CHDS

p130Cas linkage to MAPK signaling for integrins