Assembly of collagen fibrils and other multimeric structures
Diseases associated with glycosaminoglycan metabolism
Defective B4GALT7 causes EDS, progeroid type
Defective B3GALT6 causes EDSP2 and SEMDJL1
Nitric oxide stimulates guanylate cyclase
Collagen biosynthesis and modifying enzymes
O-glycosylation of TSR domain-containing proteins
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Binding and Uptake of Ligands by Scavenger Receptors
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Synthesis of substrates in N-glycan biosythesis
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
A tetrasaccharide linker sequence is required for GAG synthesis
Molecules associated with elastic fibres
Respiratory Syncytial Virus Infection Pathway
Respiratory syncytial virus (RSV) attachment and entry
Diseases associated with O-glycosylation of proteins
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Transcriptional regulation of brown and beige adipocyte differentiation
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Regulation of RUNX2 expression and activity
Signaling by ALK fusions and activated point mutants
NPAS4 regulates expression of target genes
Regulation of CDH11 Expression and Function
Regulation of Homotypic Cell-Cell Adhesion
Regulation of Expression and Function of Type II Classical Cadherins
TP53 Regulates Transcription of Cell Cycle Genes
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
NOTCH4 Intracellular Domain Regulates Transcription
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Nuclear events stimulated by ALK signaling in cancer
Post-translational modification: synthesis of GPI-anchored proteins
Constitutive Signaling by Aberrant PI3K in Cancer
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Defective Intrinsic Pathway for Apoptosis
TGF-beta receptor signaling activates SMADs
Inactivation, recovery and regulation of the phototransduction cascade
Retrograde transport at the Trans-Golgi-Network
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Incretin synthesis, secretion, and inactivation
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
NOTCH3 Intracellular Domain Regulates Transcription
Downregulation of TGF-beta receptor signaling
Deactivation of the beta-catenin transactivating complex
Anti-inflammatory response favouring Leishmania parasite infection
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
NOTCH1 Intracellular Domain Regulates Transcription
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Regulation of MECP2 expression and activity
GLI3 is processed to GLI3R by the proteasome
Ubiquitin-dependent degradation of Cyclin D
Factors involved in megakaryocyte development and platelet production
Thrombin signalling through proteinase activated receptors (PARs)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Interconversion of nucleotide di- and triphosphates
SARS-CoV-1 activates/modulates innate immune responses
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
EGR2 and SOX10-mediated initiation of Schwann cell myelination
CDK-mediated phosphorylation and removal of Cdc6
Cytosolic sensors of pathogen-associated DNA
Formation of the beta-catenin:TCF transactivating complex
Downstream signaling events of B Cell Receptor (BCR)
Nuclear Events (kinase and transcription factor activation)
Switching of origins to a post-replicative state
APC/C:Cdc20 mediated degradation of Securin
Downregulation of SMAD2/3:SMAD4 transcriptional activity
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Dectin-1 mediated noncanonical NF-kB signaling
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Regulation of PTEN stability and activity
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
Detoxification of Reactive Oxygen Species
ZBP1(DAI) mediated induction of type I IFNs
SCF-beta-TrCP mediated degradation of Emi1
Degradation of beta-catenin by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Autodegradation of the E3 ubiquitin ligase COP1
p53-Dependent G1/S DNA damage checkpoint
APC/C:Cdc20 mediated degradation of mitotic proteins
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Independent G1/S DNA damage checkpoint
APC/C-mediated degradation of cell cycle proteins
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
The role of GTSE1 in G2/M progression after G2 checkpoint
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Phase I - Functionalization of compounds
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Generation of second messenger molecules
Regulation of RUNX3 expression and activity
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Caspase activation via extrinsic apoptotic signalling pathway
TP53 Regulates Transcription of Cell Death Genes
NOTCH2 Activation and Transmission of Signal to the Nucleus
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Activation of NMDA receptors and postsynaptic events
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Cell death signalling via NRAGE, NRIF and NADE
AUF1 (hnRNP D0) binds and destabilizes mRNA
Regulation of mRNA stability by proteins that bind AU-rich elements
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Negative regulators of RIG-I/MDA5 signaling
Regulation of ornithine decarboxylase (ODC)
Cross-presentation of soluble exogenous antigens (endosomes)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Aberrant regulation of mitotic cell cycle due to RB1 defects
Prefoldin mediated transfer of substrate  to CCT/TriC
Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding
Regulation of APC/C activators between G1/S and early anaphase
Evasion by RSV of host interferon responses
Transcriptional regulation of white adipocyte differentiation
Activation of kainate receptors upon glutamate binding
Transcriptional activation of mitochondrial biogenesis
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
The role of Nef in HIV-1 replication and disease pathogenesis
Cargo trafficking to the periciliary membrane
Signaling by high-kinase activity BRAF mutants
Signaling by Non-Receptor Tyrosine Kinases
Expression and translocation of olfactory receptors
Sensory perception of sweet, bitter, and umami (glutamate) taste
MAPK targets/ Nuclear events mediated by MAP kinases
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 cascade initiated on plasma membrane
Formation of Fibrin Clot (Clotting Cascade)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G beta:gamma signalling through PI3Kgamma
Carboxyterminal post-translational modifications of tubulin
Constitutive Signaling by AKT1 E17K in Cancer
Transport of Mature mRNAs Derived from Intronless Transcripts
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ADORA2B mediated anti-inflammatory cytokines production
TP53 Regulates Transcription of DNA Repair Genes
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of the SLBP independent Mature mRNA
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Transport of inorganic cations/anions and amino acids/oligopeptides
Vasopressin regulates renal water homeostasis via Aquaporins
Glucagon signaling in metabolic regulation
E2F mediated regulation of DNA replication
Association of TriC/CCT with target proteins during biosynthesis
TAK1-dependent IKK and NF-kappa-B activation
LXRs regulate gene expression linked to cholesterol transport and efflux
Signaling by CSF1 (M-CSF) in myeloid cells
ADP signalling through P2Y purinoceptor 12
ADP signalling through P2Y purinoceptor 1
Regulation of TP53 Activity through Phosphorylation
Transcriptional regulation of pluripotent stem cells
Transport of Ribonucleoproteins into the Host Nucleus
DNA Damage/Telomere Stress Induced Senescence
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interactions of Vpr with host cellular proteins
Amino acid transport across the plasma membrane
Synthesis of PIPs at the plasma membrane
Cobalamin (Cbl, vitamin B12) transport and metabolism
Negative regulation of NMDA receptor-mediated neuronal transmission
Postmitotic nuclear pore complex (NPC) reformation
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Ras activation upon Ca2+ influx through NMDA receptor
SUMOylation of chromatin organization proteins
Assembly and cell surface presentation of NMDA receptors
EML4 and NUDC in mitotic spindle formation
NOTCH3 Activation and Transmission of Signal to the Nucleus
Presynaptic function of Kainate receptors
Amplification of signal from the kinetochores
Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal
Transport of bile salts and organic acids, metal ions and amine compounds
Sema4D induced cell migration and growth-cone collapse
Purinergic signaling in leishmaniasis infection
Regulation of MITF-M-dependent genes involved in pigmentation
Class I peroxisomal membrane protein import
SUMOylation of DNA damage response and repair proteins
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of HSF1-mediated heat shock response